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KMID : 0362319990240010076
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Journal of Korean Academy of Operative Dentistry
1999 Volume.24 No. 1 p.76 ~ p.87
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EFFECT OF ROOT-END FILLING MATERIALS ON THE ACTIVITY OF CULTURED PERIODONTAL LIGAMENT FIBROBLASTS AND OSTEOBLASTS
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양미영/Mi Young Yang
최기운/민병순/박상진/최호영/Gi woon Choi/Byung Soon Min/Sang Jin Pork/Ho Young Choi
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Abstract
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The effect of retrograde root-end filling materials(IRM, Super-EBA, Vitremer, MTA)
on human periodontal ligament fibroblasts and osteoblasts was observed. The cell
activities were evaluated by MTT assay, protein assay and alkaline phosphatase activity
examination.
The results as follows ; 1. After 24hrs culture, both E1 cells & PDL fibroblast adding
root-and filling materials were suppressed cell activities but after 48hrs, cell activities
were recovered.
2. Cell activity was lowest in Vitremer followed by IRM, MTA, Super-EBA.
3. Cell activity depression by Vitremer was not concerned with pH changes.
4. Protein synthesis by root-end dilling materials were not significant difference in Both
E1 cell & PDL fibroblasts but protein synthesis were a little increased by Super-IBA.
5. Alkaline phosphatase activity was increased in E1 cell by Super-EBA & MTA but
was not significant differences in E1 cell by IRM & Vitremer. Alkaline phosphatase
activity was a little depressed in PDL fibroblast by Vitremer.
This findings suggest that these root-end filling materials may have important roles
in promotion of PDL healing and consequently may be useful for clinical application in
apical surgery.
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KEYWORD
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